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Live data · NADAC + Part D CY24 · reviewed daily

Trimethoprim

Dihydrofolate Reductase Inhibitor Antibacterial class · 3 generic manufacturers · 3 ANDAs filed at FDA.

First FDA approval2011-06-24
Generic availableYes · 3 mfrs
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$15.8M in CY2024 Part D spend277K claims · 93K beneficiaries · 329 plans surveyed

Lowest NADAC
$1.14/unit
2 NDCs benchmarked, lowest of all strengths.
Average NADAC
$1.14
Across all dosage forms in distribution.
Highest NADAC
$1.14
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema9 entries indexed · 4 visible
What is Trimethoprim used for?

Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial medication tracked in Medicare Part D.

Is there a generic for Trimethoprim?

Yes. 3 ANDAs filed at FDA, 3 generic manufacturers currently shipping.

How much does my plan pay for Trimethoprim?

Across 329 Part D plans, Trimethoprim averages $1.14/unit (NADAC). Lowest available: $1.14/unit. Highest in distribution: $1.14/unit.

Is Trimethoprim on the FDA shortage list?

No. Trimethoprim is not currently on the FDA Drug Shortage Database.

5 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Dihydrofolate Reductase Inhibitor Antibacterial1 alternative in D1
01
Polymyxin B and Trimethoprim
Brand: Polymyxin B Sulfate and Trimethoprim
$0.459Lowest NADAC
4Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (4 approvals on file) · NADAC unit costs: CMS NADAC weekly file (2 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.