Drug class profile · refreshed daily from federal data

Proton Pump Inhibitor

10 molecules in this class, $1.50B combined CY2024 Part D spend across 85.9M claims. Class-level guide below for benefits decision-makers: where the money lives, where the savings live.

Last updated 14 Jul 2026

NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annualOrange Book: weeklyShortages: daily

Class summary at a glance.

Every drug in the Proton Pump Inhibitor class tracked across NADAC, Part D Formulary, Part D Spending, FDA Orange Book, and shortage data. Ranked below by CY24 Part D spend. Click any molecule for the full drug profile.

Molecules in class: 10tracked in Part D
CY24 Part D spend: $1.50Bcombined across class
Total Rx claims: 85.9M27.4M unique beneficiaries
Generic mfrs (active): 79across all molecules

Every drug in this class, ranked by Part D spend.

CY2024 dataCMS Part D Spending Dashboard

Omeprazole

Brand: Prilosec · 43.3M Part D claims (CY24) · 13.9M beneficiaries · First FDA approval: 2002-11-04

13 generic mfrs 0 plans require PA Discontinued

Low NADAC$0.028

→

Avg plan cost$0.510

Part D spend $516.8M 18× spread, current vs floor

Class share

34%

of class CY24 spend

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Pantoprazole

Brand: Protonix · 39.0M Part D claims (CY24) · 12.4M beneficiaries · First FDA approval: 2000-05-01

29 generic mfrs 0 plans require PA

Low NADAC$0.035

→

Avg plan cost$1.49

Part D spend $499.9M 42× spread, current vs floor

Class share

33%

of class CY24 spend

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Dexlansoprazole

Brand: Dexilant · 1.3M Part D claims (CY24) · 352K beneficiaries · First FDA approval: 2010-04-12

4 generic mfrs 0 plans require PA

Low NADAC$3.84

→

Avg plan cost$5.13

Part D spend $361.2M 1× spread, current vs floor

Class share

24%

of class CY24 spend

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Lansoprazole

Brand: Prevacid · 1.9M Part D claims (CY24) · 610K beneficiaries · First FDA approval: 1995-05-10

13 generic mfrs 0 plans require PA

Low NADAC$0.107

→

Avg plan cost$1.38

Part D spend $83.6M 13× spread, current vs floor

Class share

of class CY24 spend

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Rabeprazole

Brand: Aciphex · 447K Part D claims (CY24) · 154K beneficiaries · First FDA approval: 2013-11-08

8 generic mfrs 0 plans require PA

Low NADAC$0.217

→

Avg plan cost$0.217

Part D spend $40.6M 1× spread, current vs floor

Class share

of class CY24 spend

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Esomeprazole

Brand: NEXIUM · 183 Part D claims (CY24) · First FDA approval: 2001-03-19

4 generic mfrs 0 plans require PA

Low NADAC$0.127

→

Avg plan cost$1.59

Part D spend $44416 13× spread, current vs floor

Class share

of class CY24 spend

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Lansoprazole Dr

— Part D claims (CY24) · First FDA approval: 2022-08-08

Brand-only (no generics)

Low NADAC$0.107

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Avg plan cost$1.35

Part D spend — 13× spread, current vs floor

Class share

of class CY24 spend

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Omeprazole Sodium Bicarbonate

— Part D claims (CY24) · First FDA approval: 2017-01-30

8 generic mfrs

Low NADAC$0.569

→

Avg plan cost$0.582

Part D spend — 1× spread, current vs floor

Class share

of class CY24 spend

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Omeprazole and Sodiium Bicarbonate

— Part D claims (CY24) · First FDA approval: 2024-08-12

Brand-only (no generics)

Low NADAC—

→

Avg plan cost—

Part D spend —

Class share

of class CY24 spend

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Omeprazole and Sodium Bicarbonate

Brand: Konvomep · — Part D claims (CY24) · First FDA approval: 2004-06-15

Brand-only (no generics) 4 plans require PA

Low NADAC$0.569

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Avg plan cost$4.88

Part D spend — 9× spread, current vs floor

Class share

of class CY24 spend

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Class summary at a glance.

Every drug in this class, ranked by Part D spend.

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