A BuiltForAI Property
Live data · NADAC + Part D CY24 · reviewed daily

Omeprazole (Prilosec)

Omeprazole reduces stomach acid production, used for GERD, ulcers, and acid-related disorders.

First FDA approval2002-11-04
Generic availableYes · 13 mfrs
Shortage statusDiscontinued
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$516.8M in CY2024 Part D spend43.3M claims · 13.9M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.029/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.029
Across all dosage forms in distribution.
Highest NADAC
$0.029
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema12 entries indexed · 4 visible
What is Omeprazole used for?

Omeprazole reduces stomach acid production, used for GERD, ulcers, and acid-related disorders.

Is there a generic for Omeprazole?

Yes. 39 ANDAs filed at FDA, 13 generic manufacturers currently shipping.

How much does my plan pay for Omeprazole?

Across 329 Part D plans, Omeprazole averages $0.029/unit (NADAC). Lowest available: $0.029/unit. Highest in distribution: $0.029/unit.

Is Omeprazole on the FDA shortage list?

Omeprazole has been discontinued by its manufacturer(s).

8 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Proton Pump Inhibitor6 alternatives in D1
01
Dexlansoprazole
Brand: Dexilant
$4.21Lowest NADAC
4Generic mfrs
$361.2MCY24 Part D spend
Compare →
02
Esomeprazole
Brand: NEXIUM
$0.139Lowest NADAC
4Generic mfrs
$44,416CY24 Part D spend
Compare →
03
Lansoprazole
Brand: Prevacid
$0.108Lowest NADAC
13Generic mfrs
$83.6MCY24 Part D spend
Compare →
04
Lansoprazole Dr
Proton Pump Inhibitor
$0.108Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →
05
Omeprazole Sodium Bicarbonate
Proton Pump Inhibitor
$0.483Lowest NADAC
8Generic mfrs
CY24 Part D spend
Compare →
06
Omeprazole and Sodiium Bicarbonate
Proton Pump Inhibitor
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.