Alprostadil vs Latanoprost Ophthalmic Solution — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

Drug 1

Drug 2

Drug 3 (optional)

Drug 4 (optional)

Side by side, line by line.

Federal data onlyNo PBM pricing assumed

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11 dimensions

Prostaglandin Analog

Alprostadil

Brand: Caverject

First FDA approval: 1981-10-16

Prostaglandin Analog

Latanoprost Ophthalmic Solution

Brand: IYUZEH

First FDA approval: 2023-07-14

Lowest NADACAcquisition cost floor across all NDCs

$82.49Per unit

$10.12Per unit

Average NADACAcross all dosage forms and strengths

$152.13Up to $236.76

$10.12Up to $10.12

Generic manufacturersActive ANDA holders — FDA Orange Book

22 total ANDAs filed

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$10693Full year

—Full year

Part D claims (CY24)Total fills, all strengths

12— beneficiaries

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$891Per claim, all NDCs

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

Yes2 manufacturers

NoBrand-only