Amitriptyline vs Clomipramine — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Tricyclic Antidepressant

Amitriptyline

First FDA approval: 1977-11-21

Tricyclic Antidepressant

Clomipramine

Brand: ANAFRANIL

First FDA approval: 1989-12-29

Lowest NADACAcquisition cost floor across all NDCs

$0.035Per unit

$0.203Per unit

Average NADACAcross all dosage forms and strengths

$0.102Up to $0.284

$0.234Up to $0.257

Generic manufacturersActive ANDA holders — FDA Orange Book

1060 total ANDAs filed

1339 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$82.0MFull year

$22.2MFull year

Part D claims (CY24)Total fills, all strengths

5.7M1.5M beneficiaries

189K31K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$14Per claim, all NDCs

$117Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

576Substantial friction

312Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

6Limited friction

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

Yes10 manufacturers

Yes13 manufacturers