Crisaborole vs Apremilast — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

Drug 1

Drug 2

Drug 3 (optional)

Drug 4 (optional)

Side by side, line by line.

Federal data onlyNo PBM pricing assumed

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11 dimensions

Phosphodiesterase 4 Inhibitor

Crisaborole

Brand: Eucrisa

First FDA approval: 2017-01-30

Phosphodiesterase 4 Inhibitor

Apremilast

Brand: Otezla

First FDA approval: 2020-02-26

Lowest NADACAcquisition cost floor across all NDCs

$10.68Per unit

$89.95Per unit

Average NADACAcross all dosage forms and strengths

$11.67Up to $12.65

$93.18Up to $98.89

Generic manufacturersActive ANDA holders — FDA Orange Book

00 total ANDAs filed

515 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$13.7MFull year

$1.68BFull year

Part D claims (CY24)Total fills, all strengths

16K8K beneficiaries

332K61K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$881Per claim, all NDCs

$5,047Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

227Substantial friction

1472Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

5Limited friction

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

NoBrand-only

Yes5 manufacturers