Desipramine vs Imipramine — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

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11 dimensions

Tricyclic Antidepressant

Desipramine

Brand: Desipramine Hydrochloride

First FDA approval: 1964-11-20

Tricyclic Antidepressant

Imipramine

First FDA approval: 2010-04-16

Lowest NADACAcquisition cost floor across all NDCs

$0.146Per unit

$0.083Per unit

Average NADACAcross all dosage forms and strengths

$0.325Up to $0.719

$0.914Up to $3.78

Generic manufacturersActive ANDA holders — FDA Orange Book

530 total ANDAs filed

722 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$4.9MFull year

$6.9MFull year

Part D claims (CY24)Total fills, all strengths

80K22K beneficiaries

301K76K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$61Per claim, all NDCs

$23Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

462Substantial friction

143Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes5 manufacturers

Yes7 manufacturers