Divalproex vs Carbamazepine Er — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Mood Stabilizer

Divalproex

Brand: Depakote

First FDA approval: 1983-03-10

Mood Stabilizer

Carbamazepine Er

First FDA approval: 2022-03-31

Lowest NADACAcquisition cost floor across all NDCs

$0.055Per unit

$0.226Per unit

Average NADACAcross all dosage forms and strengths

$0.320Up to $7.47

$0.626Up to $1.14

Generic manufacturersActive ANDA holders — FDA Orange Book

2156 total ANDAs filed

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$362.1MFull year

—Full year

Part D claims (CY24)Total fills, all strengths

7.7M1.3M beneficiaries

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$47Per claim, all NDCs

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

0Zero PA friction

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes21 manufacturers

NoBrand-only