Epinephrine vs Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide — Cost, Coverage & Plan Comparison

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alpha-Adrenergic Agonist

Epinephrine

Brand: Adrenalin

First FDA approval: 1987-12-22

alpha-Adrenergic Agonist

Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan Hydrobromide

Brand: Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide

First FDA approval: 2010-06-15

Lowest NADACAcquisition cost floor across all NDCs

$1.20Per unit

$0.074Per unit

Average NADACAcross all dosage forms and strengths

$152.11Up to $359.90

$0.077Up to $0.079

Generic manufacturersActive ANDA holders — FDA Orange Book

610 total ANDAs filed

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$182.9MFull year

—Full year

Part D claims (CY24)Total fills, all strengths

875K718K beneficiaries

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$209Per claim, all NDCs

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

0Zero PA friction

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes6 manufacturers

NoBrand-only