Itraconazole vs Clotrimazole Topical — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Azole Antifungal

Itraconazole

Brand: SPORANOX

First FDA approval: 1992-09-11

Azole Antifungal

Clotrimazole Topical

Brand: Clotrimazole

First FDA approval: 2019-02-18

Lowest NADACAcquisition cost floor across all NDCs

$0.838Per unit

$0.517Per unit

Average NADACAcross all dosage forms and strengths

$4.32Up to $28.36

$0.517Up to $0.517

Generic manufacturersActive ANDA holders — FDA Orange Book

89 total ANDAs filed

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$11.6MFull year

—Full year

Part D claims (CY24)Total fills, all strengths

58K26K beneficiaries

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$198Per claim, all NDCs

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

69Minimal friction

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes8 manufacturers

NoBrand-only