Nitroglycerin vs Hydralazine and Isosorbide Dinitrate — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

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11 dimensions

Nitrate Vasodilator

Nitroglycerin

Brand: NITRO-BID

First FDA approval: 1989-12-29

Nitrate Vasodilator

Hydralazine and Isosorbide Dinitrate

Brand: BiDil

First FDA approval: 2012-12-05

Lowest NADACAcquisition cost floor across all NDCs

$0.073Per unit

$0.778Per unit

Average NADACAcross all dosage forms and strengths

$3.82Up to $50.45

$2.56Up to $4.35

Generic manufacturersActive ANDA holders — FDA Orange Book

1637 total ANDAs filed

22 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$69.4MFull year

—Full year

Part D claims (CY24)Total fills, all strengths

3.8M2.3M beneficiaries

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$18Per claim, all NDCs

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

1Minimal friction

0Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes16 manufacturers

Yes2 manufacturers