Nortriptyline vs Amoxapine — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Side by side, line by line.

Federal data onlyNo PBM pricing assumed

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11 dimensions

Tricyclic Antidepressant

Nortriptyline

Brand: PAMELOR

First FDA approval: 1977-08-01

Tricyclic Antidepressant

Amoxapine

First FDA approval: 1991-06-28

Lowest NADACAcquisition cost floor across all NDCs

$0.123Per unit

—Per unit

Average NADACAcross all dosage forms and strengths

$0.181Up to $0.262

—

Generic manufacturersActive ANDA holders — FDA Orange Book

514 total ANDAs filed

28 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$31.8MFull year

$278639Full year

Part D claims (CY24)Total fills, all strengths

1.9M560K beneficiaries

3K746 beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$17Per claim, all NDCs

$87Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

40Minimal friction

316Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes5 manufacturers

Yes2 manufacturers