Nystatin Ointment vs Nystatin Topical Powder — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

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Polyene Antifungal

Nystatin Ointment

Brand: Nystatin

First FDA approval: 2017-10-06

Polyene Antifungal

Nystatin Topical Powder

Brand: KLAYESTA

First FDA approval: 2018-05-02

Lowest NADACAcquisition cost floor across all NDCs

$0.248Per unit

$0.275Per unit

Average NADACAcross all dosage forms and strengths

$0.252Up to $0.257

$0.344Up to $0.446

Generic manufacturersActive ANDA holders — FDA Orange Book

00 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

—Full year

Part D claims (CY24)Total fills, all strengths

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

NoBrand-only