Palonosetron vs Ondansetron — Cost, Coverage & Plan Comparison

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Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Serotonin-3 Receptor Antagonist

Palonosetron

Brand: Palonosetron

First FDA approval: 2018-03-23

Serotonin-3 Receptor Antagonist

Ondansetron

Brand: ONDANSETRON

First FDA approval: 2006-11-07

Lowest NADACAcquisition cost floor across all NDCs

—Per unit

$0.064Per unit

Average NADACAcross all dosage forms and strengths

—

$0.143Up to $0.293

Generic manufacturersActive ANDA holders — FDA Orange Book

1316 total ANDAs filed

1950 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$409092Full year

$218.9MFull year

Part D claims (CY24)Total fills, all strengths

7K2K beneficiaries

14.1M8.5M beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$62Per claim, all NDCs

$16Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

—Zero PA friction

1312Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

—None

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

DiscontinuedSee drug profile

NoneClear

Generic availableFDA Orange Book

Yes13 manufacturers

Yes19 manufacturers