Perphenazine vs Perphenazine and Amitriptyline — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Phenothiazine

Perphenazine

First FDA approval: 1988-12-08

Phenothiazine

Perphenazine and Amitriptyline

First FDA approval: 1988-11-10

Lowest NADACAcquisition cost floor across all NDCs

$0.178Per unit

—Per unit

Average NADACAcross all dosage forms and strengths

$0.237Up to $0.433

—

Generic manufacturersActive ANDA holders — FDA Orange Book

936 total ANDAs filed

15 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$16.7MFull year

—Full year

Part D claims (CY24)Total fills, all strengths

287K42K beneficiaries

—— beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$58Per claim, all NDCs

—Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

184Substantial friction

122Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

Yes9 manufacturers

Yes1 manufacturers