Sertraline vs Paroxetine — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Drug 2

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Side by side, line by line.

Federal data onlyNo PBM pricing assumed

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11 dimensions

Selective Serotonin Reuptake Inhibitor (SSRI)

Sertraline

Brand: Zoloft

First FDA approval: 1992-02-11

Selective Serotonin Reuptake Inhibitor (SSRI)

Paroxetine

Brand: BRISDELLE

First FDA approval: 2003-07-30

Lowest NADACAcquisition cost floor across all NDCs

$0.032Per unit

$0.066Per unit

Average NADACAcross all dosage forms and strengths

$1.27Up to $14.95

$0.356Up to $10.77

Generic manufacturersActive ANDA holders — FDA Orange Book

1850 total ANDAs filed

22 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$247.4MFull year

$87.4MFull year

Part D claims (CY24)Total fills, all strengths

24.4M6.0M beneficiaries

5.2M1.3M beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$10Per claim, all NDCs

$17Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

0Zero PA friction

686Substantial friction

Step therapy appliedPlan-NDC pairs requiring step therapy

2Limited friction

0None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

Generic availableFDA Orange Book

Yes18 manufacturers

Yes2 manufacturers