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Live data · NADAC + Part D CY24 · reviewed daily

Desonide (Tridesilon Cream)

Desonide reduces inflammation and suppresses immune responses, used across many conditions.

First FDA approval1992-06-30
Generic availableYes · 8 mfrs
Shortage statusDiscontinued
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$14.5M in CY2024 Part D spend279K claims · 200K beneficiaries · 329 plans surveyed

Lowest NADAC
$0.208/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.275
Across all dosage forms in distribution.
Highest NADAC
$0.400
Range is tight.
Plans with PA
0 / 329
Zero PA friction — switching is purely formulary.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Desonide used for?

Desonide reduces inflammation and suppresses immune responses, used across many conditions.

Is there a generic for Desonide?

Yes. 12 ANDAs filed at FDA, 8 generic manufacturers currently shipping.

How much does my plan pay for Desonide?

Across 329 Part D plans, Desonide averages $0.275/unit (NADAC). Lowest available: $0.208/unit. Highest in distribution: $0.400/unit.

Is Desonide on the FDA shortage list?

Desonide has been discontinued by its manufacturer(s).

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Corticosteroid6 alternatives in D1
01
Triamcinolone Acetonide
Brand: KENALOG-10
$0.024Lowest NADAC
27Generic mfrs
$105.6MCY24 Part D spend
Compare →
02
Prednisone
Corticosteroid
$0.037Lowest NADAC
13Generic mfrs
$118.1MCY24 Part D spend
Compare →
03
Hydrocortisone
Brand: ANUCORT-HC
$0.064Lowest NADAC
24Generic mfrs
$93.8MCY24 Part D spend
Compare →
04
Dexamethasone
Brand: DEXTENZA
$0.030Lowest NADAC
20Generic mfrs
$35.4MCY24 Part D spend
Compare →
05
Fluocinonide
Brand: Fluocinol Pak
$0.177Lowest NADAC
16Generic mfrs
$46.3MCY24 Part D spend
Compare →
06
Methylprednisolone
Brand: DEPO-MEDROL
$0.116Lowest NADAC
16Generic mfrs
$64.4MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.