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Live data · NADAC + Part D CY24 · reviewed daily

Methylprednisolone (DEPO-MEDROL)

Methylprednisolone reduces inflammation and suppresses immune responses, used across many conditions.

First FDA approval1957-10-24
Generic availableYes · 16 mfrs
Shortage statusActive shortage
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$64.4M in CY2024 Part D spend9.0M claims · 7.1M beneficiaries · 329 plans surveyed

Lowest NADAC
$0.116/unit
20 NDCs benchmarked, lowest of all strengths.
Average NADAC
$0.139
Across all dosage forms in distribution.
Highest NADAC
$0.291
Range is tight.
Plans with PA
552 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Methylprednisolone used for?

Methylprednisolone reduces inflammation and suppresses immune responses, used across many conditions.

Is there a generic for Methylprednisolone?

Yes. 52 ANDAs filed at FDA, 16 generic manufacturers currently shipping.

How much does my plan pay for Methylprednisolone?

Across 329 Part D plans, Methylprednisolone averages $0.139/unit (NADAC). Lowest available: $0.116/unit. Highest in distribution: $0.291/unit.

Is Methylprednisolone on the FDA shortage list?

Yes. Methylprednisolone is currently listed as an active FDA shortage.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Corticosteroid6 alternatives in D1
01
Triamcinolone Acetonide
Brand: KENALOG-10
$0.024Lowest NADAC
27Generic mfrs
$105.6MCY24 Part D spend
Compare →
02
Prednisone
Corticosteroid
$0.037Lowest NADAC
13Generic mfrs
$118.1MCY24 Part D spend
Compare →
03
Hydrocortisone
Brand: ANUCORT-HC
$0.064Lowest NADAC
24Generic mfrs
$93.8MCY24 Part D spend
Compare →
04
Dexamethasone
Brand: DEXTENZA
$0.030Lowest NADAC
20Generic mfrs
$35.4MCY24 Part D spend
Compare →
05
Fluocinonide
Brand: Fluocinol Pak
$0.177Lowest NADAC
16Generic mfrs
$46.3MCY24 Part D spend
Compare →
06
Budesonide
Brand: Eohilia
$0.515Lowest NADAC
15Generic mfrs
$299.4MCY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (10 approvals on file) · NADAC unit costs: CMS NADAC weekly file (20 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.