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Live data · NADAC + Part D CY24 · reviewed daily

Upadacitinib (Rinvoq)

Janus Kinase Inhibitor class · 0 generic manufacturers · 0 ANDAs filed at FDA.

First FDA approval2019-08-16
Generic availableNo (brand-only)
Shortage statusNone
340B exposureunknown
Last updated
NADAC: weekly (every Wed)Part D Formulary: quarterlyPart D Spend: annual (CY24)Orange Book: weeklyShortages: daily
At a glance · the numbers a plan sponsor wants on screen one

$2.41B in CY2024 Part D spend327K claims · 63K beneficiaries · 329 plans surveyed

Lowest NADAC
$228.83/unit
3 NDCs benchmarked, lowest of all strengths.
Average NADAC
$306.03
Across all dosage forms in distribution.
Highest NADAC
$460.04
Range is tight.
Plans with PA
1217 / 329
Substantial PA friction across plans.

Questions a plan sponsor actually asks.

FAQPage schema11 entries indexed · 4 visible
What is Upadacitinib used for?

Upadacitinib is a Janus Kinase Inhibitor medication tracked in Medicare Part D.

Is there a generic for Upadacitinib?

No. Upadacitinib is brand-only with no generic equivalents currently in market.

How much does my plan pay for Upadacitinib?

Across 329 Part D plans, Upadacitinib averages $306.03/unit (NADAC). Lowest available: $228.83/unit. Highest in distribution: $460.04/unit.

Is Upadacitinib on the FDA shortage list?

No. Upadacitinib is not currently on the FDA Drug Shortage Database.

7 additional drug-specific questions are indexed in the page's FAQPage schema for search engines and LLM crawlers, beyond what renders visually above. View page source for the complete JSON-LD.

Same class. Different math.

Janus Kinase Inhibitor3 alternatives in D1
01
Abrocitinib
Brand: CIBINQO
$197.20Lowest NADAC
0Generic mfrs
$29.9MCY24 Part D spend
Compare →
02
Baricitinib
Brand: Olumiant
$92.29Lowest NADAC
1Generic mfrs
$56.8MCY24 Part D spend
Compare →
03
Delgocitinib
Brand: Anzupgo
Lowest NADAC
0Generic mfrs
CY24 Part D spend
Compare →

Sources · every number above traces back.

Last refresh30 May 2026

Drug identity, dosage forms, brand names: openFDA NDC Directory · First approval, ANDA history: FDA Orange Book (4 approvals on file) · NADAC unit costs: CMS NADAC weekly file (3 NDCs benchmarked) · Formulary tier and PA placement: CMS Part D Formulary file (329 plans) · Annualized spend, claims, beneficiaries: CMS Part D Spending Dashboard (CY2024) · Shortage status: FDA Drug Shortage Database · 340B exposure: HRSA OPAIS. Methodology and reproducibility notes on /methodology.