Alosetron vs Palonosetron — Cost, Coverage & Plan Comparison

Pick the drugs you want to compare.

Up to 4 drugsCross-class or same-class

Start with the molecules your plan spends the most on. Most useful comparisons live within the same therapeutic class — switching across classes requires deeper clinical review.

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Federal data onlyNo PBM pricing assumed

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11 dimensions

Serotonin-3 Receptor Antagonist

Alosetron

Brand: LOTRONEX

First FDA approval: 2015-05-26

Serotonin-3 Receptor Antagonist

Palonosetron

Brand: Palonosetron

First FDA approval: 2018-03-23

Lowest NADACAcquisition cost floor across all NDCs

$2.22Per unit

—Per unit

Average NADACAcross all dosage forms and strengths

$3.03Up to $3.85

—

Generic manufacturersActive ANDA holders — FDA Orange Book

48 total ANDAs filed

1316 total ANDAs filed

Annualized Part D spendCY2024 — CMS Part D Spending Dashboard

$14.6MFull year

$409092Full year

Part D claims (CY24)Total fills, all strengths

20K5K beneficiaries

7K2K beneficiaries

Avg cost per claimCalculated: total spend ÷ total claims

$739Per claim, all NDCs

$62Per claim, all NDCs

Part D plans surveyed2026 plan year — CMS Formulary file

329Across CMS plan year

Prior-authorization frictionPlan-NDC pairs requiring PA

416Substantial friction

—Zero PA friction

Step therapy appliedPlan-NDC pairs requiring step therapy

0None

—None

FDA shortage statusLive cross-reference vs FDA Drug Shortage Database

NoneClear

DiscontinuedSee drug profile

Generic availableFDA Orange Book

Yes4 manufacturers

Yes13 manufacturers